Endocrine Abstracts

Peripheral 18-oxocortisol level could contribute to the detection of aldosterone-producing adenoma in patients with primary aldosteronism. However, peripheral 18-oxocortisol varies among such patients, which is a big drawback concerning its clinical application. We studied 48 cases of aldosterone-producing adenoma, 35 harboring KCNJ5 mutation, to clarify the significance of clinical and pathological parameters regarding peripheral 18-oxocortisol. Peripheral 18-oxocort...

Measurement of plasma aldosterone and renin concentration, or activity, is useful for selecting antihypertensive agents as well as detecting hyperaldosteronism in hypertensive patients. However, it takes several days to get results when measured by radioimmunoassay and development of more rapid assays has been long expected. We have developed chemiluminescent enzyme immunoassays enabling the simultaneous measurement of both aldosterone and renin concentrations in ten-minutes b...

Purpose: To evaluate safety and efficacy of percutaneous radiofrequency ablation therapy for unilateral aldosterone producing adrenal adenoma in normalising aldosterone secretion.Patients: Eight cases of aldosterone producing adrenal adenoma with following conditions: i) CT detectable adenoma without any risky organs on a puncture route. ii) Intervening adipose tissue between target adenoma and adjacent risky organs (pancreas or intestine). iii) Unilater...

Introduction: Aging is associated with the pathogenesis of many endocrinological disorders, especially for functioning adrenocortical disorders. In addition, mitochondria DNA abnormalities have been reported to be correlated with aging through ROS which eventually resulted in cell senescence. We previously reported that cortisol-producing adenomas (CPA) expressed more abundant cell senescent markers including p16 and p21, compared to other hormone-producing adenomas. However, ...

Background: Adrenal venous sampling (AVS) is critical to differentiate unilateral primary aldosteronism (PA) subtype. However, there are large discrepancies between institutions in the diagnostic criteria of AVS. Especially, the most major debate is in whether cosyntropin stimulation should be used for localization diagnosis or not. Segmental AVS (S-AVS) is a refinement of central AVS (C-AVS) in which samples are taken from the tributaries of the central adrenal veins allowing...

Objective: Adrenal vein sampling (AVS) is recognised by Endocrine Society guidelines as the only reliable mean to distinguish between aldosterone producing adenomas and bilateral adrenal hyperplasia, the two most common subtypes of primary aldosteronism (PA). However, AVS protocols are not standardised and vary between centres. The objective of the present study was to assess whether the presence or absence of contralateral adrenal (CL) suppression has an impact on the postope...

The pathophysiology of aldosterone-producing adenomas (APA), especially those manifesting clinically overt hyperaldosteronism despite their small size, remains unknown. Therefore, we examined the correlation between tumor size and the status of intratumoral steroidogenic enzymes involved in aldosterone biosynthesis using immunohistochemistry. Forty patients with surgically proven APAs following adrenal venous sampling were retrospectively studied. The tumor area at the maximum...